Metabolic Research's short-term game plan calls for using these patents to develop a natural drug to effectively treat osteoarthritis and rheumatoid arthritis. Arthritis is an inflammatory condition of the joints caused by excessive expression of the cells of an enzyme called cyclooxidase-2. The release by cells of this powerful enzyme causes the tissues in and around the joints to release a hormone called prostaglandin E-2 which modulates the inflammation processes. Cyclooxydase 1 has just the opposite effect. This enzyme causes the cells to synthesize the most powerful anti-inflammatory in the body, prostaglandin E-1, commonly refered to as the "Master Hormone."
By feeding the spores certain nutrients, MRI is able to increase the metabolic processing of the nutrient to produce a special unsaturated fatty acid which is then used to supply a special fatty acid which produces prostaglandin E-1 in the body. The mushroom fungi produce a precise replication of the pre-designed engineered compound.
The natural prostaglandin E-1 modulator of the acids coupled with a natural analgesic triglycerides found in mushroom fungus produces the safest and most effective natural anti inflammatory pain medicine.
In rheumatoid arthritis, the condition is aggravated by the constant release of angiogenic growth factors. This causes a continuing sprouting of small blood vessels which leak cytokines (inflammatory cell chemicals) into the inflamed area. MRI's anti-arthritis drug will include anti-angiogenic lectins to block new blood vessel growth found in rheumatoid arthritis.
Should the company's conclusions be accurate, this design will create the most potent natural anti-inflammatory drug available.